The Unjamming Transition (UJT) is Fundamental to Wound Healing, Embryonic Development, and Cancer Invasion

Dr. Jeffrey Fredberg's laboratory investigates physical processes expressed by the eukaryotic cell, such as its deformability, contractility, malleability, and motility. His team turned attention more recently from the single cell in isolation to the cellular collective as it might pertain, for example, to disruption of the bronchial epithelial layer in asthma or tumor invasion in breast cancer. To probe these physical processes at the levels of the single cell and the cellular collective, his team developeda series of novel microscale technologies that now include magnetic twisting cytometry, Fourier-transform traction microscopy, monolayer traction microscopy, and monolayer stress microscopy. Using this suite of technologies, the team was first to show that cells comprising an epithelial collective can jam much as do coffee beans that become jammed a chute. Or instead, they can unjam and migrate, invade and spread. Taken together, this body of work has illuminated relevant but poorly understood physical processes that underlie asthma, wound healing, development, and cancer. Dr. Fredberg has served on the scientific advisory committee of the Parker B. Frances Foundation, as a full time member on three standing NIH study sections (RAP/RIBT, program project HLBP, T32 institutional training mechanism NITM), and on two NIH committees (NSF/NIH interagency panel on Research at the Interface of Life and Physical Sciences; and the Study Section Boundary Team, Pulmonary Sciences IRG

Event Speaker: 
Jeffrey J. Fredberg, Ph.D
Event Date: 
Thursday, April 22, 2021 - 12:00 to 13:00
Event Recurring: 
Yes
Event Sponsor: 
/principals/users/agrp_Pratt_MEDx
Event Co-Sponsors: 
Department of Medicine,Division of Pulmonary, Allergy, and Critical Care Medicine,Pratt School of Engineering,School of Medicine (SOM)
Event Status: 
Event Location: 
None
Event Contact ID: 
287785
Event Contact: 
Crenshaw, Donna
Event Contact Email: 
Event Contact Phone: 
919-660-1915
Event Image: 
http://calendar.duke.edu/images/2021/20210422/ec22d945293d2f2f89e906e2118d3e79-O-Calendar@Duke GPMF Pics_20210405011439PM.png
Event Sequence: 
0
Event GUID: 
CAL-2c918084-788b98aa-0178-a3077b30-000068b8demobedework@mysite.edu